BiomArker-guided Duration of Antibiotic treatment in hospitalised Patients with suspecTed Sepsis (ADAPT-Sepsis): A protocol for a multicentre randomised controlled trial.

ABSTRACT:

Aim

To describe the protocol for a multi-centre randomised controlled trial to determine whether treatment protocols monitoring daily CRP (C-reactive protein) or PCT (procalcitonin) safely allow a reduction in duration of antibiotic therapy in hospitalised adult patients with sepsis.

Design

Multicentre three-arm randomised controlled trial.

Setting

UK NHS hospitals.

Target population

Hospitalised critically ill adults who have been commenced on intravenous antibiotics for sepsis.

Health technology

Three protocols for guiding antibiotic discontinuation will be compared: (a) standard care; (b) standard care + daily CRP monitoring; (c) standard care + daily PCT monitoring. Standard care will be based on routine sepsis management and antibiotic stewardship.

SUBMITTER: Dark P 

PROVIDER: S-EPMC10572477 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature