Salivary Cystatin D Interactome in Patients with Systemic Mastocytosis: An Exploratory Study.

ABSTRACT: Mastocytosis, a rare blood disorder characterized by the proliferation of clonal abnormal mast cells, has a variegated clinical spectrum and diagnosis is often difficult and delayed. Recently we proposed the cathepsin inhibitor cystatin D-R₂₆ as a salivary candidate biomarker of systemic mastocytosis (SM). Its C₂₆ variant is able to form multiprotein complexes (mPCs) and since protein-protein interactions (PPIs) are crucial for studying disease pathogenesis, potential markers, and therapeutic targets, we aimed to define the protein composition of the salivary cystatin D-C₂₆ interactome associated with SM. An exploratory affinity purification-mass spectrometry method was applied on pooled salivary samples from SM patients, SM patient subgroups with and witho

SUBMITTER: Serrao S 

PROVIDER: S-EPMC10572539 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature