Anhydrous Alum Inhibits α-MSH-Induced Melanogenesis by Down-Regulating MITF via Dual Modulation of CREB and ERK.

ABSTRACT: Melanogenesis, the intricate process of melanin synthesis, is central to skin pigmentation and photoprotection and is regulated by various signaling pathways and transcription factors. To develop potential skin-whitening agents, we used B16F1 melanoma cells to investigate the inhibitory effects of anhydrous alum on melanogenesis and its underlying molecular mechanisms. Anhydrous alum (KAl(SO₄)₂) with high purity (>99%), which is generated through the heat-treatment of hydrated alum (KAl(SO₄)₂·12H₂O) at 400 °C, potentiates a significant reduction in melanin content without cytotoxicity. Anhydrous alum downregulates the master regulator of melanogenesis, microphthalmia-associated transcription factor (MITF), which targets key genes invol

SUBMITTER: In KR 

PROVIDER: S-EPMC10572554 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature