Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer.

ABSTRACT: Differentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of thyroid nodules in the population, it is important to understand the differences between benign and malignant thyroid cancer and the molecular alterations associated with malignancy to improve detection and signal potential diagnostic, prognostic, and therapeutic targets. Proteomics analysis of benign and malignant human thyroid tissue largely revealed changes indicating modifications in RNA regulation, a common cancer characteristic. In addition, changes in the immune system and cell membrane/endocytic processes were also suggested to be involved. Annexin A1 was considered a potential malignancy biomarker and, similarly to other annexin

SUBMITTER: Coelho M 

PROVIDER: S-EPMC10572572 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature