Comprehensive Analysis of the Transcriptome-Wide m⁶A Methylome in Shaziling Pig Testicular Development.

ABSTRACT: RNA N⁶-methyladenosine (m⁶A) modification is one of the principal post-transcriptional modifications and plays a dynamic role in testicular development and spermatogenesis. However, the role of m⁶A in porcine testis is understudied. Here, we performed a comprehensive analysis of the m⁶A transcriptome-wide profile in Shaziling pig testes at birth, puberty, and maturity. We analyzed the total transcriptome m⁶A profile and found that the m⁶A patterns were highly distinct in terms of the modification of the transcriptomes during porcine testis development. We found that key m⁶A methylated genes (AURKC, OVOL, SOX8, ACVR2A, and SPATA46) were highly enriched during spermatogenesi

SUBMITTER: Chen C 

PROVIDER: S-EPMC10572705 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature