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Inhibition of Factor XI: A New Era in the Treatment of Venous Thromboembolism in Cancer Patients?


ABSTRACT: Direct oral anticoagulants against activated factor X and thrombin were the last milestone in thrombosis treatment. Step by step, they replaced antivitamin K and heparins in most of their therapeutic indications. As effective as the previous anticoagulant, the decreased but persistent risk of bleeding while using direct oral anticoagulants has created space for new therapeutics aiming to provide the same efficacy with better safety. On this basis, drug targeting factor XI emerged as an option. In particular, cancer patients might be one of the populations that will most benefit from this technical advance. In this review, after a brief presentation of the different factor IX inhibitors, we explore the potential benefit of this new treatment for cancer patients.

SUBMITTER: Poenou G 

PROVIDER: S-EPMC10572808 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Inhibition of Factor XI: A New Era in the Treatment of Venous Thromboembolism in Cancer Patients?

Poenou Géraldine G   Heestermans Marco M   Lafaie Ludovic L   Accassat Sandrine S   Moulin Nathalie N   Rodière Alexandre A   Petit Bastien B   Duvillard Cécile C   Mismetti Patrick P   Bertoletti Laurent L  

International journal of molecular sciences 20230922 19


Direct oral anticoagulants against activated factor X and thrombin were the last milestone in thrombosis treatment. Step by step, they replaced antivitamin K and heparins in most of their therapeutic indications. As effective as the previous anticoagulant, the decreased but persistent risk of bleeding while using direct oral anticoagulants has created space for new therapeutics aiming to provide the same efficacy with better safety. On this basis, drug targeting factor XI emerged as an option. I  ...[more]

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