Functional FDG-PET: Measurement of Task Related Neural Activity in Humans-A Compartment Model Approach and Comparison to fMRI.

ABSTRACT: Neuroimaging holds an essential position in global healthcare, as brain-related disorders are a substantial and growing burden. Non-degenerative disorders such as stress, depression and anxiety share common function related traits of diffuse and fluctuating changes, such as change in brain-based functions of mood, behavior and cognitive abilities, where underlying physiological mechanism remain unresolved. In this study we developed a novel application for studying intra-subject task-activated brain function by the quantitative physiological measurement of the change in glucose metabolism in a single scan setup. Data were acquired on a PET/MR-scanner. We implemented a functional [¹⁸F]-FDG PET-scan with double boli-tracer administration and finger-tapping activation, as proof-of-

SUBMITTER: Madsen SS 

PROVIDER: S-EPMC10572846 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature