Unveiling the Hidden Power of Uromodulin: A Promising Potential Biomarker for Kidney Diseases.

ABSTRACT: Uromodulin, also known as Tamm-Horsfall protein, represents the predominant urinary protein in healthy individuals. Over the years, studies have revealed compelling associations between urinary and serum concentrations of uromodulin and various parameters, encompassing kidney function, graft survival, cardiovascular disease, glucose metabolism, and overall mortality. Consequently, there has been a growing interest in uromodulin as a novel and effective biomarker with potential applications in diverse clinical settings. Reduced urinary uromodulin levels have been linked to an elevated risk of acute kidney injury (AKI) following cardiac surgery. In the context of chronic kidney disease (CKD) of different etiologies, urinary uromodulin levels tend to decrease significantly and are strongly co

SUBMITTER: Thielemans R 

PROVIDER: S-EPMC10572911 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature