BMSC-HNC Interaction: Exploring Effects on Bone Integrity and Head and Neck Cancer Progression.

ABSTRACT: In recent research, the tumor microenvironment has been shown to attract mesenchymal stromal cells (MSCs), which is of particular interest due to its implications for cancer progression. The study focused on understanding the interaction between bone marrow-derived MSCs (BMSCs) and head and neck cancer (HNC) cells. This interaction was found to activate specific markers, notably the osteogenic marker alkaline phosphatase and the oncogene Runx2. These activations corresponded with the release of collagenase enzymes, MMP9 and MMP2. To gain insights into bone resorption related to this interaction, bovine bone slices were used, supporting the growth of "heterogeneous spheroids" that contained both BMSCs and HNC cells. Through scanning electron microscopy and energy-dispersive X-ray (EDX) anal

SUBMITTER: Eichberger J 

PROVIDER: S-EPMC10573008 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature