Synthesis, Structural Characterization, Cytotoxicity, and Protein/DNA Binding Properties of Pyridoxylidene-Aminoguanidine-Metal (Fe, Co, Zn, Cu) Complexes.

ABSTRACT: Pyridoxylidene-aminoguanidine (PLAG) and its transition metal complexes are biologically active compounds with interesting properties. In this contribution, three new metal-PLAG complexes, Zn(PLAG)(SO₄)(H₂O)].∙H₂O (Zn-PLAG), [Co(PLAG)₂]SO₄∙2H₂O (Co-PLAG), and [Fe(PLAG)₂]SO₄∙2H₂O) (Fe-PLAG), were synthetized and characterized by the X-ray crystallography. The intermolecular interactions governing the stability of crystal structure were compared to those of Cu(PLAG)(NCS)₂ (Cu-PLAG) within Hirshfeld surface analysis. The structures were optimized at B3LYP/6-31+G(d,p)(H,C,N,O,S)/LanL2DZ (Fe,Co,Zn,Cu), and stability was assessed through Natural Bond Orbital Theory and Quantum Theory of

SUBMITTER: Jevtovic V 

PROVIDER: S-EPMC10573062 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature