Tailoring Properties of Hyaluronate-Based Core-Shell Nanocapsules with Encapsulation of Mixtures of Edible Oils.

ABSTRACT: Dispersions of core-shell nanocapsules (nanoemulsion) composed of liquid oil cores and polysaccharide-based shells were fabricated with emulsification using various mixtures of edible oils and amphiphilic hyaluronate derivatized with 12-carbon alkyl chains forming the shells. Such nanocapsules, with typical diameters in the 100-500 nm range, have been previously shown as promising carriers of lipophilic bioactive compounds. Here, the influence of some properties of the oil cores on the size and stability of the capsules were systematically investigated using oil binary mixtures. The results indicated that, in general, the lower the density, viscosity, and interfacial tension (IFT) between the oil and aqueous polymer solution phases, the smaller the size of the capsules. Importantly, an une

SUBMITTER: Bednorz J 

PROVIDER: S-EPMC10573177 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature