Preventive Effect of Molecular Iodine in Pancreatic Disorders from Hypothyroid Rabbits.

ABSTRACT: Pancreatic alterations such as inflammation and insulin resistance accompany hypothyroidism. Molecular iodine (I₂) exerts antioxidant and differentiation actions in several tissues, and the pancreas is an iodine-uptake tissue. We analyzed the effect of two oral I₂ doses on pancreatic disorders in a model of hypothyroidism for 30 days. Adult female rabbits were divided into the following groups: control, moderate oral dose of I₂ (0.2 mg/kg, M-I₂), high oral dose of I₂ (2.0 mg/kg, H-I₂), oral dose of methimazole (MMI; 10 mg/kg), MMI + M-I_2,, and MMI + H-I₂. Moderate or high I₂ supplementation did not modify circulating metabolites or pancreatic morphology. The MMI group showed reductions of cir

SUBMITTER: Rodriguez-Castelan J 

PROVIDER: S-EPMC10573257 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature