HtrA3: a promising prognostic biomarker and therapeutic target for head and neck squamous cell carcinoma.

ABSTRACT:

Objective

The dysregulation of the human high-temperature requirement A (HtrA) family of serine proteases is associated with many malignancies. However, there are few reports on HtrAs in head and neck squamous cell carcinoma (HNSCC). The aim of this study was to investigate the expression, prognostic value, and biological functions of HtrAs in HNSCC.

Methods

The RNA-sequencing data and clinical data of HNSCC were downloaded from The Cancer Genome Atlas (TCGA) database. The GSE30784 and GSE31056 datasets from the Gene Expression Omnibus (GEO) database were used for further verification. This study explored the differential expression of HtrAs and assessed their potential impact on the prognosis of HNSCC patients using a survival module. Correlations between clinical character

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10573296 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature