The effects of N-acetylcysteine supplement on metabolic parameters in women with polycystic ovary syndrome: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Polycystic ovary syndrome (PCOS) is a common endocrine disease, often accompanied by metabolic disorders. Metformin, as an insulin sensitizer, is widely used to improve the metabolic function of PCOS, but may have gastrointestinal side effects. Emerging evidence suggests that N-acetylcysteine (NAC) improves metabolic parameters in PCOS and may be a potential alternative to metformin.

Methods

We searched four online databases, PubMed, Embase, Web of Science, and Cochrane Library, from inception to April 1, 2023. The I² statistic and Cochrane's Q test were employed to determine heterogeneity between studies, with an I² value >50% or p < 0.1 considered significant. The data were expressed as standardized mean differences and

SUBMITTER: Liu J 

PROVIDER: S-EPMC10573309 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature