Molecular and phenotypic distinctions of macrophages in tolerant and susceptible to hypoxia rats.

ABSTRACT: Individual hypoxia tolerance is a major influence on the course and outcome of infectious and inflammatory diseases. Macrophages, which play central roles in systemic inflammatory response and other immunity reactions, are subject to functional activation orchestrated by several transcription factors including hypoxia inducible factors (HIFs). HIF-1 expression levels and the lipopolysaccharide (LPS)-induced systemic inflammatory response severity have been shown to correlate with hypoxia tolerance. Molecular and functional features of macrophages, depending on the organisms resistance to hypoxia, can determine the severity of the course of infectious and inflammatory diseases, including the systemic inflammatory response. The purpose is the comparative molecular and functional characteriza

SUBMITTER: Dzhalilova D 

PROVIDER: S-EPMC10573310 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature