Apolipoprotein-CIII O-Glycosylation, a Link between GALNT2 and Plasma Lipids.

ABSTRACT: Apolipoprotein-CIII (apo-CIII) is involved in triglyceride-rich lipoprotein metabolism and linked to beta-cell damage, insulin resistance, and cardiovascular disease. Apo-CIII exists in four main proteoforms: non-glycosylated (apo-CIII_0a), and glycosylated apo-CIII with zero, one, or two sialic acids (apo-CIII_0c, apo-CIII₁ and apo-CIII₂). Our objective is to determine how apo-CIII glycosylation affects lipid traits and type 2 diabetes prevalence, and to investigate the genetic basis of these relations with a genome-wide association study (GWAS) on apo-CIII glycosylation. We conducted GWAS on the four apo-CIII proteoforms in the DiaGene study in people with and without type 2 diabetes (n = 2318). We investigated the relations of the identif

SUBMITTER: Naber A 

PROVIDER: S-EPMC10573541 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature