Re-examining the role of the dorsal fan-shaped body in promoting sleep in Drosophila.

ABSTRACT: The needs fulfilled by sleep are unknown, though the effects of insufficient sleep are manifold. To better understand how the need to sleep is sensed and discharged, much effort has gone into identifying the neural circuits involved in regulating arousal, especially those that promote sleep. In prevailing models, the dorsal fan-shaped body (dFB) plays a central role in this process in the fly brain. In the present study we manipulated various properties of the dFB including its electrical activity, synaptic output, and endogenous gene expression. In each of these experimental contexts we were unable to identify any effect on sleep that could be unambiguously mapped to the dFB. Furthermore, we found evidence that sleep phenotypes previously attributed to the dFB were caused by genetic manip

SUBMITTER: De J 

PROVIDER: S-EPMC10573663 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature