Structure of the Drosophila melanogaster Flight Muscle Myosin Filament at 4.7 A Resolution Reveals New Details of Non-Myosin Proteins.

ABSTRACT: Striated muscle thick filaments are composed of myosin II and several non-myosin proteins which define the filament length and modify its function. Myosin II has a globular N-terminal motor domain comprising its catalytic and actin-binding activities and a long α-helical, coiled tail that forms the dense filament backbone. Myosin alone polymerizes into filaments of irregular length, but striated muscle thick filaments have defined lengths that, with thin filaments, define the sarcomere structure. The motor domain structure and function are well understood, but the myosin filament backbone is not. Here we report on the structure of the flight muscle thick filaments from Drosophila melanogaster at 4.7 Å resolution, which eliminates previous ambiguities in non-myosin densities. The ful

SUBMITTER: Abbasi Yeganeh F 

PROVIDER: S-EPMC10573858 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature