Obesity Characteristics Are Poor Predictors of Genetic Mutations Associated with Obesity.

ABSTRACT:

Background

The genetic contribution to obesity is substantial and may underpin the altered pathophysiology. One such pathway involves melanocortin signaling in the hypothalamus. Genetic variants can cause dysregulation in the central melanocortin pathway that can result in early onset of hyperphagia and obesity. Clinically identifying patients who are at risk of known genetic mutations is challenging. The main purpose of this study was to identify associations between the clinico-demographical characteristics and the presence of a genetic mutation associated with obesity.

Methods

We tested samples from 238 adult patients with class III obesity between October 2021 to February 2023 using next-generation sequencing (NGS) (Illumina, NovaSeq 6000 Sequencing System). The results

SUBMITTER: Al-Humadi AW 

PROVIDER: S-EPMC10573901 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature