Encapsulation and Biological Activity of Hesperetin Derivatives with HP-β-CD.

ABSTRACT: The encapsulation of insoluble compounds can help improve their solubility and activity. The effects of cyclodextrin encapsulation on hesperetin's derivatives (HHSB, HIN, and HTSC) and the physicochemical properties of the formed complexes were determined using various analytical techniques. The antioxidant (DPPH^•, ABTS^•+ scavenging, and Fe²⁺-chelating ability), cytotoxic, and antibacterial activities were also investigated. The inclusion systems were prepared using mechanical and co-evaporation methods using a molar ratio compound: HP-β-CD = 1:1. The identification of solid systems confirmed the formation of two inclusion complexes at hesperetin (CV) and HHSB (mech). The identification of systems of hesperetin and its derivatives with HP-β-CD in solutions

SUBMITTER: Sykula A 

PROVIDER: S-EPMC10574185 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature