Dissecting Causal Relationships Between Gut Microbiota, Blood Metabolites, and Stroke: A Mendelian Randomization Study.

ABSTRACT:

Background and purpose

We investigated the causal relationships between the gut microbiota (GM), stroke, and potential metabolite mediators using Mendelian randomization (MR).

Methods

We leveraged the summary statistics of GM (n=18,340 in the MiBioGen consortium), blood metabolites (n=115,078 in the UK Biobank), and stroke (cases n=60,176 and controls n=1,310,725 in the Global Biobank Meta-Analysis Initiative) from the largest genome-wide association studies to date. We performed bidirectional MR analyses to explore the causal relationships between the GM and stroke, and two mediation analyses, two-step MR and multivariable MR, to discover potential mediating metabolites.

Results

Ten taxa were causally associated with stroke, and stroke led to changes in 27 taxa. In t

SUBMITTER: Wang Q 

PROVIDER: S-EPMC10574297 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature