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Coordination Complexes Built from a Ditopic Triazole-Pyrazole Ligand with Antibacterial and Antifungal Performances.


ABSTRACT: Four mononuclear complexes (H3O){[NiL3](ClO4)3} (1), [CoL3](ClO4)2·2H2O (2), [CdL2Cl2] (3) and [CuL3](NO3)2 (4) have been prepared employing a newly synthesized 1,2,4-triazole ligand: 3-(3,5-dimethyl-1H-pyrazol-1-yl)-1H-1,2,4-triazole (L). The structures of the complexes, which crystallized in P63/m (1), P-1 (2), P1 (3), and P21/c (4), are reviewed within the context of the cooperative effect of the hydrogen bonding network and counter anions on the supramolecular formations. Moreover, within the framework of biological activity examination, these compounds showed favorable antibacterial performances compared to those of various species of bacteria, including both Gram-positive and Gram-negative strains. Significant antifungal inhibitory activity towards Fusarium oxysporum f. sp. albedinis fungi was recorded for 3 and 4 over the ligand L.

SUBMITTER: Draoui Y 

PROVIDER: S-EPMC10574422 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Coordination Complexes Built from a Ditopic Triazole-Pyrazole Ligand with Antibacterial and Antifungal Performances.

Draoui Youssef Y   Radi Smaail S   El Massaoudi Mohamed M   Bahjou Yousra Y   Ouahhoud Sabir S   Mamri Samira S   Ferbinteanu Marilena M   Benabbes Redouane R   Wolff Mariusz M   Robeyns Koen K   Garcia Yann Y  

Molecules (Basel, Switzerland) 20230925 19


Four mononuclear complexes (H<sub>3</sub>O){[NiL<sub>3</sub>](ClO<sub>4</sub>)<sub>3</sub>} (<b>1</b>), [CoL<sub>3</sub>](ClO<sub>4</sub>)<sub>2</sub>·2H<sub>2</sub>O (<b>2</b>), [CdL<sub>2</sub>Cl<sub>2</sub>] (<b>3</b>) and [CuL<sub>3</sub>](NO<sub>3</sub>)<sub>2</sub> (<b>4</b>) have been prepared employing a newly synthesized 1,2,4-triazole ligand: 3-(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-1<i>H</i>-1,2,4-triazole (<b>L</b>). The structures of the complexes, which crystallized in <i>P63/m</i>  ...[more]

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