Melatonin Activation by Human Cytochrome P450 Enzymes: A Comparison between Different Isozymes.

ABSTRACT: Cytochrome P450 enzymes in the human body play a pivotal role in both the biosynthesis and the degradation of the hormone melatonin. Melatonin plays a key role in circadian rhythms in the body, but its concentration is also linked to mood fluctuations as well as emotional well-being. In the present study, we present a computational analysis of the binding and activation of melatonin by various P450 isozymes that are known to yield different products and product distributions. In particular, the P450 isozymes 1A1, 1A2, and 1B1 generally react with melatonin to provide dominant aromatic hydroxylation at the C₆-position, whereas the P450 2C19 isozyme mostly provides O-demethylation products. To gain insight into the origin of these product distributions of the P450 isozymes,

SUBMITTER: Mokkawes T 

PROVIDER: S-EPMC10574541 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature