Hesperidin Anti-Osteoporosis by Regulating Estrogen Signaling Pathways.

ABSTRACT: Osteoporosis (OP) is distinguished by a reduction in bone mass and degradation of bone micro-structure, frequently resulting in fractures. As the geriatric demographic expands, the incidence of affected individuals progressively rises, thereby exerting a significant impact on the quality of life experienced by individuals. The flavonoid compound hesperidin has been subject to investigation regarding its effects on skeletal health, albeit the precise mechanisms through which it operates remain ambiguous. This study utilized network pharmacology to predict the core targets and signaling pathways implicated in the anti-OP properties of hesperidin. Molecular docking and molecular dynamics simulations were employed to confirm the stability of the interaction between hesperidin and the core targ

SUBMITTER: Hu HY 

PROVIDER: S-EPMC10574669 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature