The Minimum Methionine Requirement for Adults Aged ≥60 Years Is the Same in Males and Females.

ABSTRACT: The minimum methionine requirement in the presence of excess dietary cysteine has not been determined in older adults. This study aimed to determine the minimum methionine requirement in healthy older adults using the indicator amino acid oxidation (IAAO) method. Fifteen healthy adults ≥ 60 years of age received seven methionine intakes (0 to 20 mg/kg/d) plus excess dietary cysteine (40 mg/kg/d). Oxidation of the indicator, L-[1-¹³C]phenylalanine (F¹³CO₂), was used to estimate the mean minimum methionine requirement using a change-point mixed-effect model. There was no statistical difference between male and female requirement estimates, so the data were pooled to generate a mean of 5.1 mg/kg/d (R_m² = 0.46, R_c² =

SUBMITTER: Paoletti A 

PROVIDER: S-EPMC10574673 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature