Phloretin Transfersomes for Transdermal Delivery: Design, Optimization, and In Vivo Evaluation.

ABSTRACT:

Background

Phloretin (Phl) is a flavonoid compound that contains multiple phenolic hydroxyl groups. It is found in many plants, such as apple leaves, lychee pericarp, and begonia, and has various biological activities, such as antioxidant and anticancer effects. The strong hydrogen bonding between Phl molecules results in poor water solubility and low bioavailability, and thus the scope of the clinical application of Phl is limited. Therefore, it is particularly important to improve the water solubility of Phl for its use to further combat or alleviate skin aging and oxidative damage and develop antioxidant products for the skin. The purpose of this study was to develop and evaluate a phloretin transfersome gel (PTG) preparation for transdermal drug delivery to improve the bioavail

SUBMITTER: Wang J 

PROVIDER: S-EPMC10574780 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature