Photoperiod alters testicular methyltransferase complex mRNA expression in Siberian hamsters.

ABSTRACT: Exposure to long photoperiods stimulates, whereas exposure to short photoperiods transiently inhibit testicular function in Siberian hamsters via well-described neuroendocrine mechanisms. However, less is known about the intra-testicular regulation of these photoperiod-mediated changes. N6-methyladenosine (m⁶A) is one of the most common mRNA modifications in eukaryotes, with alterations in m⁶A mRNA methylation affecting testis function and fertility. We hypothesized that genes controlling m⁶A methylation such as methyltransferase-like-3 (Mettl3) and -14 (Mettl14) and Wilms' tumor-1 associated protein (Wtap), part of an mRNA methylating methyl-transferase complex, or the fat-mass-and-obesity-associated (Fto) and the α-ketoglutarate-dependent dioxygenase alkB

SUBMITTER: Rader MA 

PROVIDER: S-EPMC10575611 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature