Single-nuclei characterization of pervasive transcriptional signatures across organs in response to COVID-19.

ABSTRACT:

Background

Infection by coronavirus SARS-CoV2 is a severe and often deadly disease that has implications for the respiratory system and multiple organs across the human body. While the effects in the lung have been extensively studied, less is known about the impact COVID-19 has across other organs.

Methods

Here, we contribute a single-nuclei RNA-sequencing atlas comprising six human organs across 20 autopsies where we analyzed the transcriptional changes due to COVID-19 in multiple cell types. The integration of data from multiple organs enabled the identification of systemic transcriptional changes.

Results

Computational cross-organ analysis for endothelial cells and macrophages identified systemic transcriptional changes in these cell types in COVID-19 samples. In

SUBMITTER: COVID Tissue Atlas Consortium 

PROVIDER: S-EPMC10575628 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature