Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function.

ABSTRACT: Dopamine system dysfunction is implicated in adolescent-onset neuropsychiatric disorders. Although psychosis symptoms can be alleviated by antipsychotics, cognitive symptoms remain unresponsive and novel paradigms investigating the circuit substrates underlying cognitive deficits are critically needed. The frontal cortex and its dopaminergic input from the midbrain are implicated in cognitive functions and undergo maturational changes during adolescence. Here, we used mice carrying mutations in Arc or Disc1 to model mesofrontal dopamine circuit deficiencies and test circuit-based neurostimulation strategies to restore cognitive functions. We found that in a memory-guided spatial navigation task, frontal cortical neurons were activated coordinately at the decision-making point

SUBMITTER: Mastwal S 

PROVIDER: S-EPMC10575630 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature