Mapping the spatial variation of mitral valve elastic properties using air-pulse optical coherence elastography.

ABSTRACT: The mitral valve is a highly heterogeneous tissue composed of two leaflets, anterior and posterior, whose unique composition and regional differences in material properties are essential to overall valve function. While mitral valve mechanics have been studied for many decades, traditional testing methods limit the spatial resolution of measurements and can be destructive. Optical coherence elastography (OCE) is an emerging method for measuring viscoelastic properties of tissues in a noninvasive, nondestructive manner. In this study, we employed air-pulse OCE to measure the spatial variation in mitral valve elastic properties with micro-scale resolution at 1 mm increments along the radial length of the leaflets. We analyzed differences between the leaflets, as well as between regions of th

SUBMITTER: Vekilov DP 

PROVIDER: S-EPMC10575695 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature