In vitro Assessment of the Effects of Silybin on CYP2B6-mediated Metabolism.

ABSTRACT: Silybin is a flavonol compound with a variety of physiological properties, such as hepatoprotective, anti-fibrogenic, and hypocholesterolemic effects. Although the in vivo and in vitro effects of silybin are frequently reported, studies on herb-drug interactions have yet to be performed. With the discovery of multiple important substrates of CYP2B6 recently, there is a growing body of evidence indicating that CYP2B6 plays a much larger role in human drug metabolism than previously thought.The purpose of this study is to determine how silybin affects the CYP2B6 enzyme's activity, as well as to clarify the molecular mechanisms for inhibition by silybin. The results showed that silybin inhibited CYP2B6 activity in liver microsomes in a non-competitive manner, with IC₅₀

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10575715 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature