Prognostic indices in diffuse large B-cell lymphoma: a population-based comparison and validation study of multiple models.

ABSTRACT: Currently, the International Prognostic Index (IPI) is the most used and reported model for prognostication in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). IPI-like variations have been proposed, but only a few have been validated in different populations (e.g., revised IPI (R-IPI), National Comprehensive Cancer Network IPI (NCCN-IPI)). We aimed to validate and compare different IPI-like variations to identify the model with the highest predictive accuracy for survival in newly diagnosed DLBCL patients. We included 5126 DLBCL patients treated with immunochemotherapy with available data required by 13 different prognostic models. All models could predict survival, but NCCN-IPI consistently provided high levels of accuracy. Moreover, we found similar 5-year overall su

SUBMITTER: Jelicic J 

PROVIDER: S-EPMC10575851 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature