Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity.

ABSTRACT: Cancer immunotherapy has transformed traditional treatments, with immune checkpoint blockade being particularly prominent. However, immunotherapy has minimal benefit for patients in most types of cancer and is largely ineffective in some cancers (such as pancreatic cancer and glioma). A synergistic anti-tumor response may be produced through the combined application with traditional tumor treatment methods. Radiotherapy (RT) not only kills tumor cells but also triggers the pro-inflammatory molecules' release and immune cell infiltration, which remodel the tumor microenvironment (TME). Therefore, the combination of RT and immunotherapy is expected to achieve improved efficacy. In this review, we summarize the effects of RT on cellular components of the TME, including T cell receptor reperto

SUBMITTER: Liu S 

PROVIDER: S-EPMC10575861 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature