Increased blood immune regulatory cells in severe COVID-19 with autoantibodies to type I interferons.

ABSTRACT: The hallmark of severe COVID-19 is an uncontrolled inflammatory response, resulting from poorly understood immunological dysfunction. While regulatory T (Treg) and B (Breg) cells, as the main elements of immune homeostasis, contribute to the control of hyperinflammation during COVID-19 infection, we hypothesized change in their levels in relation to disease severity and the presence of autoantibodies (auto-Abs) to type I IFNs. Cytometric analysis of blood of 62 COVID-19 patients with different severities revealed an increased proportion of conventional (cTreg; CD25⁺FoxP3⁺) and unconventional (uTreg; CD25^-FoxP3⁺) Tregs, as well as the LAG3⁺ immune suppressive form of cTreg/uTreg, in the blood of severe COVID-19 cases compared to the mil

SUBMITTER: Saheb Sharif-Askari F 

PROVIDER: S-EPMC10575900 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature