Histological diagnosis of polyploidy discriminates an aggressive subset of hepatocellular carcinomas with poor prognosis.

ABSTRACT:

Background

Although genome duplication, or polyploidization, is believed to drive cancer evolution and affect tumor features, its significance in hepatocellular carcinoma (HCC) is unclear. We aimed to determine the characteristics of polyploid HCCs by evaluating chromosome duplication and to discover surrogate markers to discriminate polyploid HCCs.

Methods

The ploidy in human HCC was assessed by fluorescence in situ hybridization for multiple chromosomes. Clinicopathological and expression features were compared between polyploid and near-diploid HCCs. Markers indicating polyploid HCC were explored by transcriptome analysis of cultured HCC cells.

Results

Polyploidy was detected in 36% (20/56) of HCCs and discriminated an aggressive subset of HCC that typically showed

SUBMITTER: Matsuura T 

PROVIDER: S-EPMC10576083 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature