Characteristics and anatomic location of PD-1⁺TCF1⁺ stem-like CD8 T cells in chronic viral infection and cancer.

ABSTRACT: CD8 T cells play an essential role in antitumor immunity and chronic viral infections. Recent findings have delineated the differentiation pathway of CD8 T cells in accordance with the progenitor-progeny relationship of TCF1⁺ stem-like and Tim-3⁺TCF1^- more differentiated T cells. Here, we investigated the characteristics of stem-like and differentiated CD8 T cells isolated from several murine tumor models and human lung cancer samples in terms of phenotypic and transcriptional features as well as their location compared to virus-specific CD8 T cells in the chronically lymphocytic choriomeningitis virus (LCMV)-infected mice. We found that CD8 tumor-infiltrating lymphocytes (TILs) in both murine and human tumors exhibited overall similar phenotypic and transc

SUBMITTER: Im SJ 

PROVIDER: S-EPMC10576122 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature