Molecular determinants for cold adaptation in an Antarctic Na⁺/K⁺-ATPase.

ABSTRACT: Enzymes from ectotherms living in chronically cold environments have evolved structural innovations to overcome the effects of temperature on catalysis. Cold adaptation of soluble enzymes is driven by changes within their primary structure or the aqueous milieu. For membrane-embedded enzymes, like the Na⁺/K⁺-ATPase, the situation is different because changes to the lipid bilayer in which they operate may also be relevant. Although much attention has been focused on thermal adaptation within lipid bilayers, relatively little is known about the contribution of structural changes within membrane-bound enzymes themselves. The identification of specific mutations that confer temperature compensation is complicated by the presence of neutral mutations, which can be more num

SUBMITTER: Galarza-Munoz G 

PROVIDER: S-EPMC10576127 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature