Localized microbially induced inflammation influences distant healthy tissues in the human oral cavity.

ABSTRACT: Variation in human immune response to the same bacterial or viral pathogen is well established in the literature. Variation in immune response to microbial challenge has also been observed within the human oral cavity. Our recent study focused on characterizing observed variations in microbially induced gingival inflammation-resulting in three distinct clinical Inflammatory Responder Types (IRTs): High-IRT, Low-IRT, and Slow-IRT. Here, we applied a high-resolution temporal multiomic analysis during microbially induced inflammation in order to characterize the effects of localized oral inflammation on distant healthy tissues in young healthy adults. Our results highlight a nonlocalized subclinical effect with alterations in proinflammatory host mediators and an ecological shift toward dysbi

SUBMITTER: Kerns KA 

PROVIDER: S-EPMC10576129 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature