Effects of (-)-MBP, a novel 5-HT_2C agonist and 5-HT_2A/2B antagonist/inverse agonist on brain activity: A phMRI study on awake mice.

ABSTRACT: A novel serotonin ligand (-)-MBP was developed for the treatment of schizophrenia that has 5-HT_2A/2B antagonist activity together with 5-HT_2C agonist activity. The multi-functional activity of this novel drug candidate was characterized using pharmacological magnetic resonance imaging. It was hypothesized (-)-MBP would affect activity in brain areas associated with sensory perception. Adult male mice were given one of three doses of (-)-MBP (3.0, 10, 18 mg/kg) or vehicle while fully awake during the MRI scanning session and imaged for 15 min post I.P. injection. BOLD functional imaging was used to follow changes in global brain activity. Data for each treatment were registered to a 3D MRI mouse brain atlas providing site-specific information on 132 different brain are

SUBMITTER: Sathe PK 

PROVIDER: S-EPMC10576165 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature