Obesity and Risk of Recurrence in Patients With Breast Cancer Treated With Aromatase Inhibitors.

ABSTRACT:

Importance

Clinical studies confirm that obesity is a risk factor for recurrence in postmenopausal women with hormone receptor-positive (HR+) breast cancer. Evidence suggests that women with obesity do not obtain similar protection from aromatase inhibitors as women with healthy weight.

Objective

To examine the associations of body mass index (BMI) with recurrence.

Design, setting, and participants

The cohort study was conducted using data from the Danish Breast Cancer Group and enrolled postmenopausal women diagnosed with stage I to III HR+ breast cancer from 1998 through 2016. Data analysis was conducted from November 2022 to April 2023.

Exposures

BMI was classified as (1) healthy weight (18.5-24.9), (2) overweight (25.0-29.9), (3) obesity (30.0-34.9), and (4

SUBMITTER: Harborg S 

PROVIDER: S-EPMC10576219 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature