A cross-species proteomic map reveals neoteny of human synapse development.

ABSTRACT: The molecular mechanisms and evolutionary changes accompanying synapse development are still poorly understood^1,2. Here we generate a cross-species proteomic map of synapse development in the human, macaque and mouse neocortex. By tracking the changes of more than 1,000 postsynaptic density (PSD) proteins from midgestation to young adulthood, we find that PSD maturation in humans separates into three major phases that are dominated by distinct pathways. Cross-species comparisons reveal that human PSDs mature about two to three times slower than those of other species and contain higher levels of Rho guanine nucleotide exchange factors (RhoGEFs) in the perinatal period. Enhancement of RhoGEF signalling in human neurons delays morphological maturation of dendritic spines and funct

SUBMITTER: Wang L 

PROVIDER: S-EPMC10576238 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature