Inflammatory bowel disease and the associated risk of dry eye and ocular surface injury: a nationwide matched cohort study.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) is associated with lacrimal gland dysfunction and ocular inflammation. The objective of this research was to elucidate the temporal relationships between IBD, dry eye disease (DED), and corneal surface damage.

Methods

In a matched nationwide cohort study, we evaluated the risk of DED and corneal surface damage associated with IBD. Multivariable Cox proportional hazards regression analyses were implemented to estimate the risk of ocular complications.

Results

A total of 54,293 matched pairs were included for analyses. The median follow-up time was 8.3 years (interquartile range: 5.5 - 10.5). The period incidence of DED was 8.18 and 5.42 per 1000 person-years in the IBD and non-IBD groups, respectively. After adjusting for con

SUBMITTER: Ko YT 

PROVIDER: S-EPMC10576268 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature