Dataset Information

Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort.

ABSTRACT:

Background

Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.

Methods

This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring.

Results

At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HR_adj (95%CI): 1.01 (1.00, 1.03)) and BMI (HR_adj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk.

Conclusions

In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.

Trial registration

This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870 ).

SUBMITTER: Shyam S

PROVIDER: S-EPMC10576302 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Publications

Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort.

Shyam Sangeetha S García-Gavilán Jesús Francisco JF Paz-Graniel Indira I Gaforio José J JJ Martínez-González Miguel Ángel MÁ Corella Dolores D Martínez J Alfredo JA Alonso-Gómez Ángel M ÁM Wärnberg Julia J Vioque Jesús J Romaguera Dora D López-Miranda José J Estruch Ramon R Tinahones Francisco J FJ Lapetra José J Serra-Majem J Luís JL Bueno-Cavanillas Aurora A Tur Josep A JA Sánchez Vicente Martín VM Pintó Xavier X Matía-Martín Pilar P Vidal Josep J Vázquez Clotilde C Daimiel Lidia L Ros Emilio E Fernandez-Aranda Fernando F Nishi Stephanie K SK Garcia-Regata Oscar O Toledo Estefania E Asensio Eva M EM Castañer Olga O Garcia-Rios Antonio A Torres-Collado Laura L Gómez-Gracia Enrique E Zulet M Angeles MA Ruiz Nuria Goñi NG Casas Rosa R Cano-Ibáñez Naomi N Tojal-Sierra Lucas L Gómez-Perez A M AM Sorlí Jose V JV Cinza-Sanjurjo Sergio S Martín-Peláez Sandra S Peña-Orihuela Patricia J PJ Oncina-Canovas Alejandro A Perez-Araluce Rafael R Zomeño María Dolores MD Chaplin Alice A Delgado-Rodríguez Miguel M Babio Nancy N Fitó Montserrat M Salas-Salvadó Jordi J

BMC medicine 20231013 1

<h4>Background</h4>Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.<h4>Methods</h4>This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. B ...[more]

PMID: 37833678

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Dataset Information

Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort.

Background

Methods

Results

Conclusions

Trial registration

Publications

Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort.

Similar Datasets

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