Chronic neuroinflammation during aging leads to cholinergic neurodegeneration in the mouse medial septum.

ABSTRACT:

Background

Low-grade, chronic inflammation in the central nervous system characterized by glial reactivity is one of the major hallmarks for aging-related neurodegenerative diseases like Alzheimer's disease (AD). The basal forebrain cholinergic neurons (BFCN) provide the primary source of cholinergic innervation of the human cerebral cortex and may be differentially vulnerable in various neurodegenerative diseases. However, the impact of chronic neuroinflammation on the cholinergic function is still unclear.

Methods

To gain further insight into age-related cholinergic decline, we investigated the cumulative effects of aging and chronic neuroinflammation on the structure and function of the septal cholinergic neurons in transgenic mice expressing interleukin-6 under the GFAP

SUBMITTER: Gamage R 

PROVIDER: S-EPMC10576363 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature