Microbial synthesis of the plant natural product precursor p-coumaric acid with Corynebacterium glutamicum.

ABSTRACT:

Background

Phenylpropanoids such as p-coumaric acid represent important precursors for the synthesis of a broad range of plant secondary metabolites including stilbenoids, flavonoids, and lignans, which are of pharmacological interest due to their health-promoting properties. Although extraction from plant material or chemical synthesis is possible, microbial synthesis of p-coumaric acid from glucose has the advantage of being less expensive and more resource efficient. In this study, Corynebacterium glutamicum was engineered for the production of the plant polyphenol precursor p-coumaric acid from glucose.

Results

Heterologous expression of the tyrosine ammonia-lyase encoding gene from Flavobacterium johnsoniae enabled the conversion of endogenously provided tyrosine to p-c

SUBMITTER: Mutz M 

PROVIDER: S-EPMC10576375 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature