Microglia preserve visual function loss in the aging retina by supporting retinal pigment epithelial health.

ABSTRACT:

Background

Increased age is a risk factor for the development and progression of retinal diseases including age-related macular degeneration (AMD). Understanding the changes that occur in the eye due to aging is important in enhancing our understanding of AMD pathogenesis and the development of novel AMD therapies. Microglia, the resident brain and retinal immune cells are associated with both maintaining homeostasis and protection of neurons and loss of microglia homeostasis could be a significant player in age related neurodegeneration. One important characteristic of retinal aging is the migration of microglia from the inner to outer retina where they reside in the subretinal space (SRS) in contact with the retinal pigment epithelial (RPE) cells. The role of aged subretinal micr

SUBMITTER: Karg MM 

PROVIDER: S-EPMC10576380 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature