Characterization of essential eggshell proteins from Aedes aegypti mosquitoes.

ABSTRACT:

Background

Up to 40% of the world population live in areas where mosquitoes capable of transmitting the dengue virus, including Aedes aegypti, coexist with humans. Understanding how mosquito egg development and oviposition are regulated at the molecular level may provide new insights into novel mosquito control strategies. Previously, we identified a protein named eggshell organizing factor 1 (EOF1) that when knocked down with RNA interference (RNAi) resulted in non-melanized and fragile eggs that did not contain viable embryos.

Results

In this current study, we performed a comprehensive RNAi screen of putative A. aegypti eggshell proteins to identify additional proteins that interact with intracellular EOF1. We identified several proteins essential for eggshell formation in

SUBMITTER: Isoe J 

PROVIDER: S-EPMC10576393 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature