A study on the preparation conditions of lidocaine microemulsion based on multi-objective genetic algorithm.

ABSTRACT: Background: Topical lidocaine microemulsion preparations with low toxicity, low irritation, strong transdermal capability and convenient administration are urgently needed. Methods: Box-Behnken design was performed for three preparation conditions of 5% lidocaine microemulsions: mass ratio of the mass ratio of surfactant/(oil phase + surfactant) (X₁), the mass ratio of olive oil/(α-linolenic acid + linoleic acid) (X₂) and the water content W% (X₃). Then, five multi-objective genetic algorithms were used to optimize the three evaluation indices to optimize the effects of lidocaine microemulsion preparations. Finally, the ideal optimization scheme was experimentally verified. Results: Non-dominated Sorting Genetic Algorithm-II was used fo

SUBMITTER: Qiao Y 

PROVIDER: S-EPMC10576434 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature