Cerebrovascular reactivity to carbon dioxide tension in newborns: data from combined time-resolved near-infrared spectroscopy and diffuse correlation spectroscopy.

ABSTRACT:

Significance

Critically ill newborns are at risk of brain damage from cerebrovascular disturbances. A cerebral hemodynamic monitoring system would have the potential role to guide targeted intervention.

Aim

To obtain, in a population of newborn infants, simultaneous near-infrared spectroscopy (NIRS)-based estimates of cerebral tissue oxygen saturation (StO2) and blood flow during variations of carbon dioxide tension (pCO2) levels within physiologic values up to moderate permissive hypercapnia, and to examine if the derived estimate of metabolic rate of oxygen would stay constant, during the same variations.

Approach

We enrolled clinically stable mechanically ventilated newborns at postnatal age >24  h without brain abnormalities at ultrasound. StO2 and blood flow inde

SUBMITTER: Passera S 

PROVIDER: S-EPMC10576436 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature