A pilot genome-wide association study meta-analysis of gastroparesis.

ABSTRACT:

Background

Gastroparesis (GP) is characterized by delayed gastric emptying in the absence of mechanical obstruction.

Objective

Genetic predisposition may play a role; however, investigation at the genome-wide level has not been performed.

Methods

We carried out a genome-wide association study (GWAS) meta-analysis on (i) 478 GP patients from the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium (GpCRC) compared to 9931 population-based controls from the University of Michigan Health and Retirement Study; and (ii) 402 GP cases compared to 48,340 non-gastroparesis controls from the Michigan Genomics Initiative. Associations for 5,811,784 high-quality SNPs were tested on a total of 880 GP patients and 58,271 contro

SUBMITTER: Tavares LC 

PROVIDER: S-EPMC10576603 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature